Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus.
Gracia G Morales, Juan J JJ Picazo, Elvira E Baos, Francisco J FJ Candel, Ana A Arribi, Beatriz B PelÃ¡ez, Raquel R Andrade, MarÃa-Angeles MA de la Torre, JosÃ© J Fereres, Miguel M SÃ¡nchez-GarcÃa
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From April through June 2008, we identified 12 patients in the intensive care unit and 3 patients on other wards infected with methicillin-resistant Staphylococcus aureus that was also resistant to linezolid. We investigated the mechanism of resistance--point mutations in domain V of 23S ribosomal RNA (rRNA) or presence of the cfr gene--involved in the outbreak.