Squamous Cell Carcinoma Antigen 1 (SCCA-1)

Squamous Cell Carcinoma Antigen 1 (SCCA-1)

SCCA-1 (squamous cell carcinoma antigen 1) is coded by the SERPINB3 gene (serpin peptidase inhibitor, clade B (ovalbumin), member 3) and has a molecular weight of ~44.5 kD, and is a subfraction of the tumor associated antigen TA-4.  SCCA-1 is a useful tumor marker for detecting, staging & for monitoring response to therapy in patients with squamous cell carcinoma of the lung.  It may also act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells and may also function as an inhibitor of UV-induced apoptosis via suppression of the JNK1 activity (c-JUN (NH (2)-terminal Kinase)).


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r-SCCA-1 Ag.
r-SCCA-1 Ag.

Source: Human CHO Cell Line. Concentration: ≥ 100 µg/mL. Form: Liquid in Phosphate Buffered Saline pH 7.4 ± 0.1

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