ProteOn™ Manager Software

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Overview

Protocol Editor

Screenshot showing edits to protocols using the Protocol Editor feature of the ProteOn Manager software.

Sample Management

Screenshot of sample layouts.
Sample position is indicated by color-coordinated graphics that represent the sample position in the protocol. Pull-down menus in the sample panels allow the user to easily switch sample locations while retaining all sample information.

Autoprocessing

Screenshot showing the use of auto processing feature of the ProteOn Manager™ software.
The Autoprocess button can be used to adjust the baseline and injection alignment parameters and to remove artifacts in data.

Data Analysis
data analysis

Data analysis report generated by ProteOn Manager™ software. Software wizards allow step-by-step data collection for kinetic, equilibrium, and concentration analysis. Each analysis mode allows the user to define analysis parameters, perform calculations, and review and print results.



ProteOn Manager™ software guides the user through protein interaction studies, allowing sophisticated experiments to be completed with ease. A single software interface controls instrument setup, experiment design, data collection, and analysis.

Instrument Control
The instrument control panel includes maintenance wizards that direct the user to weekly and monthly cleaning protocols to keep the instrument running at optimum performance. Additionally, the instrument control panel logs all instrument functions in a searchable and exportable database.

Protocol Design
The protocol editor offers a variety of formats for creating a protocol easily. Users may design templates, create custom protocols, or use the automatic protocol option depending on their workflow. Samples may be imported or manually entered using copy and paste commands or using group functions for iterative tasks. Pull-down menus help navigate samples into flexible locations. Once samples are entered, data types and concentration can be selected to aid in downstream analysis. Graphics are shown to help visualize orientation of sample injection flow.

Sample Management
Sample layouts are visually displayed in several ways. Position is indicated by color-coordinated graphics that represent the sample position in the protocol. Pull-down menus in the sample panels allow the user to easily switch sample locations while retaining all sample information.

Data Collection
The software interface allows users to visualize real-time interactions on all 36 spots. Raw data collected from the instrument can be processed and analyzed with ProteOn Manager software. Data at any stage — raw, processed, or analyzed — can be exported. Sensorgrams may be exported in either a metafile or data format for use in presentations and publications.

Autoprocessing
Data processing is easy with the click of a single button with undo functions to illustrate the effects of different processing parameters to a data set. Users can instantly adjust the baseline and injection alignment parameters and remove artifacts using the Autoprocess button. Data processing functions can also be performed manually.

The software supports a comprehensive set of referencing options, including interspot or channel referencing, real-time injection reference, double referencing, and excluded volume correction for solvents like DMSO. Referencing is selected and applied with the click of a button.

Data Analysis
Data analysis is made simple through the use of intuitive software wizards. Wizards allow step-by-step data collection for kinetic, equilibrium, and concentration analysis. Association, dissociation, and affinity constants are reported in the data table and can be easily exported. Each analysis mode allows the user to define analysis parameters, perform calculations, and review and print results. Analysis with molecular weight normalization is available. Seven kinetic fit models are supported, including Langmuir 1:1, Langmuir with drift, Langmuir mass transfer, bivalent analyte, heterogeneous analyte, heterogeneous ligand, and conformational change, as well as separate off-rate only analysis.

ProteOn Manager Software, Security Edition
New compliance features enable the user to turn on security features that comply with U.S. FDA 21 CFR Part 11 regulations. Features of the Security Edition software include audit trails, electronic signatures, data validation, user logins and permissions, and closed-system security. Signatures can be verified, ensuring data consistency within the instrument.

ProteOn Manager Software #176-0200
ProteOn Manager™ Software

176-0200
Software for ProteOn XPR36 instrument control, experiment design, data collection, and analysis, CD-ROM, includes HASP key

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ProteOn Manager™ Software, Security Edition

176-0210
1-user license, security edition software for ProteOn XPR36 instrument control, allows U.S. FDA 21 CFR Part 11 compliance, CD-ROM, includes HASP key

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Number Description Options
6300 Guide to SPR Data Analysis on the ProteOn XPR36 System, Rev A Click to download
6299 Guide to SPR Data Processing on the ProteOn XPR36 Protein Interaction Assay System, Rev A Click to download
5390 ProteOn XPR36 Protein Interaction Array System Brochure, Rev D Click to download [ Add to Cart (Free) ]
5968 Screening and Characterization of Human Immunoglobulin G Binding Peptides Using the ProteOn XPR36 Protein Interaction Array System, Rev A Click to download [ Add to Cart (Free) ]
5538 Analyzing Protein Interactions With the ProteOn XPR36 Protein Interaction Array System, Rev D Click to download [ Add to Cart (Free) ]
5413 ProteOn XPR36 Hardware Product Information Sheet, Rev B Click to download
5627 ProteOn Manager Software Product Information Sheet, Rev C Click to download [ Add to Cart (Free) ]
5404 ProteOn Sensor Chips Product Information Sheet, Rev E Click to download [ Add to Cart (Free) ]
5410 ProteOn Protocol Development Kits Product Information Sheet, Rev B Click to download [ Add to Cart (Free) ]
5409 Protein Interaction Analysis Ordering Information Sheet, Rev E Click to download [ Add to Cart (Free) ]
5819 ProteOn XPR36 Protein Interaction Array System: Regulatory Tools for Drug Development Product Focus, Rev A Click to download
5965 Rapid, High-Throughput Screening of Protein Kinase Inhibitors Using the ProteOn XPR36 Protein Interaction Array System, Rev B Click to download
5846 Determining the Binding Kinetics of HIV-1 Nucleocapsid Protein to Six Densities of Oligonucleotide Using the ProteOn XPR36 Protein Interaction Array System, Rev A Click to download
5412 Antibody Characterization and Development: ProteOn XPR36 Protein Interaction Array System Application Guide, Rev C Click to download
5540 Screening, Ranking, and Epitope Mapping of Anti-Human IL-9 Supernatants, Rev A Click to download
5820 Rapid Screening and Selection of Optimal Antibody Capturing Agents Using the ProteOn XPR36 Protein Interaction Array System, Rev A Click to download [ Add to Cart (Free) ]
3172 Rapid and Efficient Determination of Kinetic Rate Constants Using the ProteOn XPR36 Protein Interaction Array System, Rev B Click to download
5360 Rapid and Detailed Analysis of Multiple Antigen-Antibody Pairs Using the ProteOn XPR36 Protein Interaction Array System, Rev A Click to download
5367 Rapid Optimization of Immobilization and Binding Conditions for Kinetic Analysis of Protein-Protein Interactions Using the ProteOn XPR36 Protein Interaction Array System, Rev A Click to download
5368 Anaylsis of Multiple Protein-Protein Interactions Using the ProteOn XPR36 Protein Interaction Array System, Rev B Click to download
5358 Mechanisms of Protein-Protein Binding: Double-Mutant Cycle Analysis Using the ProteOn XPR36 System, Rev A Click to download
5821 Guide to Ligand Immobilization Protocol Guide, Rev A Click to download
5822 How to Perform Excluded Volume Correction on the ProteOn XPR36 Protein Interaction System Protocol Guide, Rev C Click to download
5797 Rapid Assay Development and Optimization for Small Molecule Drug Discovery, Rev B Click to download [ Add to Cart (Free) ]
5679 Applications of the ProteOn GLH Sensor Chip: Interactions Between Proteins and Small Molecules, Rev A Click to download [ Add to Cart (Free) ]
5449 Applications of the ProteOn NLC Sensor Chip: Antibody-Antigen, DNA-Protein, and Protein-Protein Interactions, Rev B Click to download [ Add to Cart (Free) ]
5434A ProteOn XPR36 Protein Interaction Array System Folder. (Contains bulletins 3172, 5358, 5360, 5367, 5368, 5390, 5404, 5409, 5410, 5413, 5538, and 5465 DVD, depending on availability) [ Add to Cart (Free) ]
6161 Highly Efficient Lipoparticle Capture and SPR Binding Kinetics of a Membrane Protein Using the ProteOn XPR36 Protein Interaction Array System, Rev A Click to download [ Add to Cart (Free) ]
6449 Novel Liposome-Capture Surface Chemistries to Analyze Drug-Lipid Interaction using the ProteOn XPR36 System, Rev A Click to download
6414 ProteOn XPR36 Experimental Design and Application Guide, Rev A Click to download