Bio-Beads™ SM-2 Resin



  Bio-Beads SM-2 Adsorbent
Chemical nature Polystyrene-divinyl-benzene
Polarity Nonpolar
Dipole moment 0.3 Debye
Average pore diameter (dry beads) 90 Å
Wet density (g/cc) 1.02
Capacity (Triton X-100 detergent) g/g 0.07
Bio-Beads SM-2 Adsorbents Applications
Application Reference
Trace organics Wigilius, B., Boren, H., Cvarlberg, G. E., in water Grimvall, A., Lundgren, B. V. and Savenhed,R., J. Chromatog., 391, 169–182 (1987).
Junk, G.A., Richard, J. J., Grieser, M. D.,Witiak, D., Witiak, J. L., Arguello, M. D.,Vick, R., Svec, H. J., Fritz, J. S. and Calder,G. V., J. Chromatogr., 99, 745–762 (1974).
Jahanir, L. M. and Samuelson, O.,J.Chromatogr., 193, 197–206 (1980).
Moore, R.A. and Karasek, F. W., Inter. J.Environ. Anal. Chem., 17, 187–202 (1984).
Chlorinated hydrocarbons in water Picer, N. and Picer, M., J. Chromatogr., 193, 357–369 (1980).
Separation of nitro- and chlorophenols Grieser, M.D. and Pietrzyk, D. J., Anal. Chem., 45, 1348–1353 (1973).
Organic bases Chu, C. and Pietrzyk, D. J., Anal. Chem., 46 (3), 330–340 (1974).
Retention and sorption of sulfas Rotsch, T. D., Sydor, R. J. and Pietrzyk, D. J., J. Chrom. Sci., 17, 339–344 (1979).
Separation of cannabinoids from cannabis extract Hendriks, H., Batterman, S., Bos, R., Huizing, H. J. amd Malingre, Th. M., J. Chromatog., B205, 444–450 (1981).
Determination of benzo[a] pyrene in cigarette smoke condensate Robinson, J. L., Marshall, M. A., Draganjac,M. E. amd Noggle, L. C., Anal. Chim. Acta,115, 229–238 (1980).
Narcotic antagonists in human urine Digregorio, G.J., J. Chromatogr., 101, 424-427 (1974).
Drugs in urine Roerig, D. L., Lewand, D., Mueller, M. and Wang, R. I. H., J. Chromatogr., 110, 349–359 (1975).
Bastos, M. L., Jukofsly, D. and Mule, S. J., J. Chromatogr., 81, 93 (1973).
Morphine and codeine in urine Ulrich, L. and Ruegsegger, P., Arch. Toxicol., 45, 241–248 (1980). German.
Morphine in urine Kullberg, M. P. and Gorodetzky, C. W., Clinical Chem., 20 (2), 177–183 (1974).
Methaqualone in blood plasma Hux, R. A., Mohammed, H. Y. and Cantwell, F. F., Anal. Chem., 54, 113–117 (1982).
Drugs in blood Schlicht, H. J. and Gelbke, H. P.,Z. Rechtsmedizin, 81, 25–30 (1978).
Pharmaceutical drug syrups Mohammed, H. Y. and Cantwell, F. F., Anal. Chem., 50 (3), 491–496 (1978).
Extraction of drugs from human stomach fluid Ibrahim G., Andryauskas, S. amd Bastos, M. L., J. Chromatrogr., 108, 107–116 (1975).
Polar and non-polar drug metabolites Dieterle, W., Faigle, J. W. and Mory, H., J. Chromatogr., 168, 27–34 (1979).
Purification of aminobenzyl-phosphonic acid Landt, M., Boltz, S. C. amd Butler, L. G., Biochem., 17 (5), 915–919 (1978).
Free rhodamine Spack, E. G., Jr., Packard, B., Wier, M. L. and Edidin, M., Anal. Biochem., 158, 233–237 (1986).
Crude plasma clean-up Tamura, M., Harris, T. M. Higashimori, K., Sweetman, B. J., Blair, I. A. and Inagami, T., Biochem., 26, 2797–2806 (1987).
Leukotrienes from plasma prostaglandins Salari, H. and Steffenrud, S., J. Chromatogr., 378, 35–44 (1986).
Prostaglandins Hamberg, M., Anal. Biochem., 55, 368–378 (1973).
Prostaglandins adsorption from biological fluid Leffler, C. W., Desiderio, D. M. and Wakelyn, C. E., Prostaglandins, 21, 227–241 (1981).
Isolation of proline and proline from fossil bone Stafford, T. W., Duhamel, R. C., Haynes, C. V. and Brendel, K., Life Sciences, 31, 931–938 (1982).
Anabolic steroids in animal tissue and urine Verbeke, R., J. Chromatogr., 177, 69–84 (1979).
Steroids from urine Shacklleton, C. H. L., Sjovall, J. and Wisen, O., Clin. Chim. Acta, 27, 354–356 (1970).
Extraction of steroids Bradlow, H. L., Steroids, 11, 265 (1968).
Bile acids Okuyama, S., Uemura, D. amd Hirata, Y., Bulletin of Chemical Society of Japan, 52 (1), 124–126 (1979).
–206 (1974).
Cobalamins Fenton, W. A. and Rosenberg, L. E., Anal. Biochem., 90, 119–125 (1978).
Phosphatidyl-ethanolamine from plasma Salari, H., J. Chromatogr., 419, 103–111 (1987).
Glucuronides Delaborde, S., Loosli, H. R., Ponelle, M., Griesser, R. amd Maurer, G., J. High Resolution Chromatography & Chromatography Communications, 10, 71–76 (1987).
Impregnation of resin with pentafluoro-benzyl bromide microbial fatty acid analysis Rosenfeld, J. M., Hammerberg, O. and Orvidas, M. C., J. Chromatogr., 378, 9–16 (1986).
Plant hormones Stafford, A. E., Kunhle, J. A., Corse, J. and Hautala, E., J. Chromatogr., 294, 485–488 (1984).
Captopril (derivatized in blood) Funke. P.T., Ivashkiv. E., Malley. M.F. and Cohen, A.I., Anal. Chem., 52, 1086–1089, (1980).
Flavonoids from aqueous fractions Rosler, K. H. and Goodwin, R. S., J. Natural Products, 47 (1), 188 (1983).
Acid dyes Uematsu, T., Kurita, T. and Hamada, A., J. Chromatogr., 172, 327–334 (1979).
Naringin and limonin from grapefruit juice Chandler, B. V. and Johnson, R.l., Proc. Int. Soc. Citriculture, 2, 885–888 (1981).
Triadimefon in grape wine Nickless, G. and Spitzer, T., J. Chromatogr., 208, 409–413 (1981).
Indium treated adsorbent to concentrate humic complexes Hiraide, M., Arima, Y. and Mizuike, A., Anal. Chim. Acta, 200, 171–179 (1987).
Hydrocarbons, PCBs and fatty acids in sea water Gomez-Bellnchon, J. I., Grimalt, J. O. and Albaiges, J., Environ. Sci. Technol., 22, 667–685 (1988).
Polynuclear hydrocarbons from water Navratil, J. D., Sievers, R. E. and Walton, H. F., Anal. Chem., 49 (14), 2260–2263 (1977).
Aminocarb insecticide from water Levesque, D. and Mallet, V. N., Intern. J. Environ. Anal. Chem., 16, 139–147 (1983).
Carbamate insecticides Sundaram, K. M. S., Szeto, S. Y. and Hindle, R., J. Chromatogr., 177, 29–34 (1979).
Chlorinated pesticides McNeil, E. E. and Otsen, R., J. Chromatogr., 132, 277–286 (1977).
Ethyl and methyl parathion Paschal, D. D., Bicknell, R. and Dresbach, D., Anal. Chem., 49, (11) 1551–1554 (1977).
Fenitrothion and its degradation products Volpe, G. and Mallet, V. N., Chromatographia, 14 (6), 333–336 (1981).
Organophos-phorous pesticides LeBel, G. L., Williams, D. T., Griffith, G. and Benoit, F. M., J. Assoc. Off. Anal. Chem., 62, No. 2, 241–249 (1979).
Carboxylic acid from aqueous solutions Jahanginr, JL. M. and Samuelson, O., J. Chromatogr., 237, 371–379 (1982).
Use in HPLC column as ground material Baum, R. G., Saetre, R. and Cantwell, F. F., Anal. Chem., 52 (1), 15–19 (1980).
Benzenesulfonic acids Rotsch, T. D. and Pietryzk, D. J., Anal.Chem., 52 (8),, 1323–1327 (1980).
Use in TLC as stationary phase Pietryzk, D. J. Ritsch, T. D. and Leuthauser, S. W., J. Chromatogr. Sci., 17, 555–561 (1979).
Metal cation adsorption Mackey, D. J., J. Chromatogr., 242, 275–287 (1982).
Metal ion adsorption using pyrocatechol loaded adsorbent Brajter, K., Olbrych-Sleszynska, E. and Staskiewicz, M., Talanta, 35 (1), 65–67 (1988).
Resin impregnation with TBP for extracting actinides from fission products Green, L. W., Elliot, N. L. and Longhurst, T. H., Anal. Chem., 55, 2394–2398 (1983).
Triton X-100 detergent Holloway, P. W., Anal. Chem., 53, 304–308 (1973).
Drexler, G., Eichinger, A., Wolf, C. and Seighart, W., J. Immun. Methods, 95,117–122 (1986).
Bonomi, F. and Kurtz, D. M., Jr., Anal. Biochem., 142, 226-231 (1984).
Welling, G. W., et. al., J. Chromatogr., 297, 101 (1984).
Cholate detergent Bonomo, E. A. and Swaney, J. B., J. Lipid Research, 29, 380–384 (1988).
–335 (1987).
Deoxycholate Horigome, T. and Sugano, H.,Anal. Biochem., 130, 393-396 (1983).
Lorusso, D. J. and Green, F. A., Science, 188,66 (1974).
–7696 (1971).
NP-40 detergent Momoi, T., Biochem. Biophys. Res. Commun., 87, 541–549 (1979).
Emulgen 911 Gibson, G. G., and Schenkman, F. B., J. Biol. Chem., 253, 5957–5963 (1978).
–13000 (1982).
Emulphogene BC-720 Brunch, R. C., Thotakura, N. R. and Bahl, O. P., J. Biol. Chem., 261 (20), 9450–9460 (1986).
Coating microtiter plates with detergent soluble membrane proteins
–122 (1986).
Compounds Concentrated or Separated by Bio-Beads SM-2 Adsorbents
Trace organics Morphine
PAH compounds Methaqualone
Hydrocarbons and PCBs Sulfas
Aminocarb insecticides Free rhodamine
Carbamate insecticides Prostaglandins
Ethyl and methyl parathion Steroids
Metals Bile acids
Carboxylic acids Hormones
Phenolic acids Purines and pyrimidines
Flavonoids Acid dyes
Mycotoxins Naringin and limonin
Proline and hydroxyproline Detergents
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Bio-Beads SM-2 Resin is a nonpolar polystyrene adsorbent composed of analytical-grade, neutral, macroporous polymeric beads for use in hydrophobic interaction chromatography. Bio-Beads SM-2 Resin has a high surface area for adsorbing organics with MW <2,000 from aqueous solutions. These beads can be used in aqueous solution and with solvents including alcohols, petroleum ether, diethyl ether, and hexane, or with solvent mixtures, without expansion or contraction of the beads.

Bio-Beads SM-2 Resin is useful for the adsorption of nonpolar substances or surface active agents from aqueous solutions.

Applications and Uses of Bio-Beads SM-2 Resin

  • Removal of detergents such as Triton X-100
  • Removal of organics such as polyaromatic hydrocarbons from water
  • Cleanup of drugs from plasma and urine
  • Cleanup of biological metabolites and pesticides
  • Extraction of dyes and mycotoxins from food products
More Information

Bio-Beads™ SM-2 Hydrophobic Adsorbents Application Bibliography (Bulletin 1461)

Larger volumes and special packaging for industrial applications are available upon request. Please contact your local Bio-Rad representative to discuss your requirements.


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Bio-Beads SM-2 Adsorbents

100 g, nonpolar polystyrene adsorbents for hydrophobic interaction chromatography, 300–1,180 µm bead size, for organics MW <2,000

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1461 Bio-Beads SM-2 Hydrophobic Adsorbents Application Bibliography Click to download
LIT195 Instruction Manual, Bio-Beads SM Hydrophobic and Polar Interaction Adsorbents, Rev B Click to download