GS-900™ Calibrated Densitometer

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GS-900 Calibrated Densitometer – Gel Imaging Systems

Overview

Model Comparability Study

Biologics Analysis Workflow
Model Comparability Study

Obtaining cGMP Approval for Validated SDS-PAGE Assays with the GS-900™ Calibrated Densitometer

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Biologics Analysis Workflow™

Biologics Analysis Workflow

Integrated Protein Electrophoresis Solutions

Faster, easier, and more accurate analysis tools optimized for cGMP labs

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The GS-900 calibrated densitometer is designed to reproducibly image gels, blots, and film and quantitate proteins across a wide dynamic range. The GS-900 densitometry system uses transmissive and reflective imaging to scan chromogenic samples at the optimal detection wavelength. The three-color red, green, and blue CCD imaging technology enables accurate, reproducible quantitation with a wide variety of common stains. To meet cGMP environment needs, the GS-900 offers a security edition software module and IQ/OQ kit.

Applications and Uses

  • Imaging of diverse samples on 1-D and 2-D gels, colorimetric dot and slot blots, film-based chemiluminescent blots, and autoradiograms
  • Protein quantitation for Coomassie Blue- and silver-stained gels over a wide dynamic range of 0–3.4 OD
  • Scanning large gels — oversized 29 × 33 cm imaging area
  • Rapid image acquisition and analysis with intuitive, user-friendly Image Lab™ software

Features and Benefits of the GS-900 Calibrated Densitometer

  • Automatic self-calibration before each run
  • Image Lab™ software greatly simplifies image analysis
    • Automated analysis saves time and ensures consistency between runs
    • Includes detailed tutorials; no previous imaging experience required to produce optimum gel and blot images
    • Flexible analysis — simply modify user settings to match SOPs and fine-tune band detection, background level, and other settings
    • Easy reporting with the ability to create customized reports
  • Meets 21 CFR Part 11 regulatory requirements with an optional Image Lab software module (170-9691)
  • 16-bit precision and 36.3 μm resolution for the analysis of very close bands on a gel
  • Sealed imaging area to accommodate wet samples of variable thickness

Related Products

The GS-900 calibrated densitometry system and Image Lab software are part of the Biologics Analysis Workflow™ — an integrated suite of products designed and validated to assess the purity or identity of biological products in a cGMP environment.

The Biologics Analysis Workflow provides:

  • Increased electrophoresis throughput
  • Simplified, sensitive and reproducible gel staining
  • Accurate and reproducible imaging
  • Easy data analysis and report generation
Calibration frequency Automatic calibration before every scan
21 CRF Part 11 Yes (optional software package)
Acquisition software ImageLab™ software ≥5.0
Light source LED
Wavelength 400–750 nm
Absorbance range 0.0 to 3.4 OD Transmissive
0.0 to 2.7 OD RD reflective
Transmissive scan area 29 × 33 cm
Reflective scan area 29 × 33 cm
Bit depth 16-bit grayscale
Minimum pixel size 36.3 µm (700 dpi)
Image Lab™ software OS compatibility Windows XP, 7
Connection type USB 2.0
Imager dimensions (W x L x H) 62.7 × 37.6 × 18.5 cm
Imager weight 16.1 kg
Applications Densitometry
Calibrated colorimetric gel and blot quantitation
GS-900™ calibrated densitometry system
GS-900™ Calibrated Densitometry System

170-7991
Gel densitometry system, includes scanner, cables, PC-compatible Image Lab™ software, optional 21 CFR Part 11 and Installation Qualification/Operations Qualification Module

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GS-900™ Calibrated Densitometer Regulatory Tools Package
GS-900™ Calibrated Densitometer Regulatory Tools Package

170-7993
Pkg of 1, set of protocols for validating the calibration of GS-900™ calibrated densitometer (#170-7991), Image Lab™ Security Edition with 21 CFR Part 11 Module

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GS-900™ Installation Qualification/Operations Qualification (IQ/OQ) Kit
GS-900™ Installation Qualification/Operations Qualification (IQ/OQ) Kit

170-7994
Pkg of 1, set of protocols for validating the calibration of GS-900™ calibrated densitometer (#170-7991)

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Image Lab™ Software

170-9690
Software, PC or Mac, for automated image capture, optimization, and 1-D data analysis, for use with Gel Doc™ EZ, Gel Doc XR+, ChemiDoc™ XRS+, ChemiDoc MP, and GS-900™ imaging systems

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Image Lab™ Software, Security Edition, 1 license
Image Lab™ Software, Security Edition, 1 license

170-9691
21 CFR Part 11 module for Image Lab software, 1 license, use with GS-900™, Gel Doc™ EZ, Gel Doc XR+, ChemiDoc™ XRS+, and ChemiDoc MP imaging systems

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Image Lab™ Software, Security Edition, 5 licenses
Image Lab™ Software, Security Edition, 5 licenses

170-9692
21 CFR Part 11 module for Image Lab software, 5 licenses, use with GS-900™, Gel Doc™ EZ, Gel Doc XR+, ChemiDoc™ XRS+, and ChemiDoc MP imaging systems

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Image Lab™ Software, Security Edition, 10 licenses
Image Lab™ Software, Security Edition, 10 licenses

170-9693
21 CFR Part 11 module for Image Lab software, 10 licenses, use with GS-900™, Gel Doc™ EZ, Gel Doc XR+, ChemiDoc™ XRS+, and ChemiDoc MP imaging systems

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Number Description Options
10031959 Instruction Manual, Image Lab Software for the GS-900 Calibrated Densitometer, Rev B Click to download
6007 Criterion TGX Precast Gels Product Information Sheet, Rev B Click to download [ Add to Cart (Free) ]
6040 Electrophoresis Guide, Interactive PDF, Rev B Click to download
4006028 Instruction Manual, Laemmli Sample Buffer, Rev J Click to download
10032602 QC Colloidal Coomassie Stain Manual, Rev A Click to download
10033507 Biologics Analysis Workflow Product Information Sheet Click to download
6421 Image Lab™ Software for the GS-900™ Densitometer Quick Start Guide, Rev A Click to download
10030885 Installing your GS-900™ Calibrated Densitometer Quick Start Guide, Rev C Click to download
6387 Biologics Analysis Workflow™ Model Comparability Study — Obtaining cGMP Approval for Validated SDS-PAGE Assays with the GS-900™ Calibrated Densitometer, Rev B Click to download
6385 Biologics Analysis Workflow™ Brochure, Rev A Click to download
6126 Imaging Systems, Computer Specifications, Rev D Click to download
2895 Protein Blotting Guide, Interactive PDF, Rev B Click to download
2651 2-D Electrophoresis for Proteomics: A Methods and Product Manual, Rev F Click to download