Bio-Rad Customized Process Skids

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Overview

Specifications
Pressure rating   Up to 6 bar
Temperature range   Ambient: 4–30°C
Process fluids: 4–60°C
Inline dilution capabilities   1:2 to 1:10
Gradient capabilities   10–90%
Material Process tube
Frame
Bubble trap
Gaskets
Stainless steel 316L ASME
Stainless steel 304L
Glass or acrylic
EPDM or GYLON
Bio-Rad Process Chromatography Skid 00 Video


Bio-Rad's process chromatography skid 00 is the industry's first compact skid designed for small-scale GMP biopharmaceutical manufacturing. The skid can be interchanged with multiple columns ranging in diameter from 70 to 300 mm with flow rates from 5 to 120 L/hr. To learn more click the video.

Bio-Rad Process Chromatography Skid 01–05 Specifications
Process
Skid
Category
Flow Rate, L/hr Process Pipe
(ASME BPE)
Maximum Dimensions
(L x W x H), mm
Surface Finish, µm Bubble Trap
Volume, L
Rotary
Diaphragm Pump
Multihead
Diaphragm Pump
00* 5–120 N/A N/A 1,060 x 750 x 610 Ra ≤0.4 0.2
01 5–250 15–165 3/8" 1,500 x 1,000 x 1,700 Ra ≤0.4 0.4
02 25–600 54–540 1/2" 1,500 x 1,000 x 1,700 Ra ≤0.4 1.0
03 40–1,200 105–1,050 3/4" 1,500 x 1,000 x 1,700 Ra ≤0.4 2.7
04 300–3,150 315–3,150 1" Upon request Ra ≤0.4 4.6
05 300–4,500 450–5,400** 1.5" Upon request Ra ≤0.4 4.6

* For more information, request or download bulletin 5997.
** With lobe pump.

Process Skid Categories
Process
Skid
Category
Flow Range (l/h) Process Pipe
(ASME BPE)
Maximum Dimensions
(L x W x H), mm
Surface Finish (µm) Bubble Trap
Volume (l)
Rotary
Diaphragm Pump
Multihead
Diaphragm Pump
0 1–150 3.6–41 1/4" 1,500 x 1,000 x 1,700 Ra≤0.8 0.4
1 5–250 15–165 3/8" 1,500 x 1,000 x 1,700 Ra≤0.4 0.4
2 25–600 54–540 1/2" 1,500 x 1,000 x 1,700 Ra≤0.4 1
3 40–1,200 105–1,050 3/4" 1,500 x 1,000 x 1,700 Ra≤0.4 2.7
4 300–3,150 315–3,150 1" 2,500 x 1,500 x 2,200 Ra≤0.4 4.6
5 450–5,400 450–5,400* 1.5" 2,700 x 1,650 x 2,200 Ra≤0.4 4.6

* With Lobe pump.

Step and Linear Gradient

Step and linear gradient on process chromatography skid size 3 at 1,000 L/H.

Process Skid Software

System overview screen: Intuitive user interface allows for simple data input and user-friendly programming of process sequences.

Process Skid Performance

Compatibility of process skid category and column diameter; isocratic system (flow rate, l/h).


Compatibility of process skid category and column diameter; gradient system (flow rate, l/h).

To read more click here

Bio-Rad Process Chromatography Skid Schematic

Many options exist for customization of the Bio-Rad process chromatography skid.

 

Bio-Rad Process Chromatography Skid 00

The versatile Bio-Rad process chromatography skid 00 is a benchtop system for small-scale GMP biopharmaceutical manufacturing processes. The skid 00 is a self-contained system that integrates all necessary hardware components. A wireless tablet PC with SCADA software is used to run the chromatography process and to communicate with the PLC. The housing is made of stainless steel with closed construction design.

Key Features and Benefits

  • Designed for easy cleaning and maintenance
  • Configured for simultaneous inline dilution and gradient operation for high performance and reduced cost
  • User-friendly software meets U.S. FDA 21 CFR Part 11 requirements
  • Documentation for regulatory submission is included

Bio-Rad Process Chromatography Skid 01–05

The Bio-Rad process chromatography skid 01–05 allows different options to be integrated into a core platform. Isocratic and gradient systems are optimized for column diameter and process requirements. Other system components, such as pump size and bubble trap volume, are also designed to order.

You may specify combinations of sensors, including flow, pH, conductivity, temperature, pressure, and air sensors. Other options include the orientation and number of valves and ports, an enhanced pressure rating, and clean-in-place and steam-in-place designs.

Options that can be integrated on a process skid include:

  • Multihead dosing pumps
  • Gradient function (controlled by flow rate or flow rate and conductivity)
  • Additional inlet and outlet valves
  • Pressure sensor (before filter or after column)
  • Additional filter
  • Air sensor (after bubble trap or before pump)
  • Conductivity monitor (before column)
  • Temperature sensor (before column)
  • pH monitor (before column)
  • Sampling valve (after column)
  • HETP software
  • Position detector for valves
  • Sterilization-in-place

The computer-driven operation system is passcode protected to record all events and actions in accordance with GMP compliance guidelines. The system controller runs in the Windows operating system. Its simple, user-friendly interface enables touch-screen input of data and programming commands. The software meets U.S. FDA 21 CFR Part 11 requirements.

For more information, please contact your Bio-Rad process sales representative or technical support.

Number Description Options
5739 Packing and Slurry-in-Place Procedures for CHT Ceramic Hydroxyapatite Using a Bio-Rad InPlace Process-Scale Chromatography Column, Rev A Click to download [ Add to Cart (Free) ]
5657 Bio-Rad Process Chromatography Skid Product Information Sheet, Rev B Click to download [ Add to Cart (Free) ]
5488 State-of-the-Art Solutions for Process-Scale Chromatography, Rev C Click to download [ Add to Cart (Free) ]
5662 Process Chromatography Applications Laboratory Brochure, Rev B Click to download
5663 Bio-Rad InPlace Columns Product Information Sheet, Rev B Click to download [ Add to Cart (Free) ]
5661 Bio-Rad Media Transfer Device, Rev B Click to download [ Add to Cart (Free) ]
5620 Bio-Rad Media Slurry Tank Product Information Sheet, Rev A Click to download
5659 Bio-Rad Mainframe Lifting Accessory Product Information Sheet, Rev B Click to download [ Add to Cart (Free) ]
5614 Bio-Rad Bubble Trap Product Information Sheet, Rev B Click to download
5615 Isolation Two-Way Valves Product Information Sheet, Rev A Click to download
5619 Pressure Relief Valve Product Information Sheet, Rev A Click to download
5616 Liquid Pump for Inflatable Seals Product Information Sheet, Rev B Click to download
5618 Pressure Gauge Product Information Sheet, Rev A Click to download