Gene:  VKORC1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 23-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin and it is the product of this gene that is sensitive to warfarin. In humans mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and in humans and rats with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq Jul 2008]

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PrimePCR™ SYBR® Green Assay: VKORC1, Human
vitamin K epoxide reductase complex, subunit 1

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0038134
Info:   Same primer pair as used in probe assay qHsaCEP0040857
List Price:    $125.00
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PrimePCR™ Probe Assay: VKORC1, Human
vitamin K epoxide reductase complex, subunit 1

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0040857
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: VKORC1, Human
vitamin K epoxide reductase complex, subunit 1

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5006415
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0038134; exonic
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression Probe Assay: VKORC1, Human
vitamin K epoxide reductase complex, subunit 1

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5031142
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0040857; exonic
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: VKORC1, Human
vitamin K epoxide reductase complex, subunit 1

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5031143
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0040857; exonic
 
Fluorophore:   HEX
List Price:    $190.00
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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