Gene:  TTN, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions a N-terminal I-band and a C-terminal A-band. The I-band which is the elastic part of the molecule contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline glutamate valine and lysine. The A-band which is thought to act as a protein-ruler contains a mixture of immunoglobulin and fibronectin repeats and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere respectively so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and therefore to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9 and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq Feb 2012]

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PrimePCR™ SYBR® Green Assay: TTN, Human
titin

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0020293
Info:   Same primer pair as used in probe assay qHsaCIP0032710
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PrimePCR™ Probe Assay: TTN, Human
titin

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0032710
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.L7304P, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2500672
Info:   64nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.L7304P, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2500673
Info:   64nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.R16298C, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2501006
Info:   67nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.R16298C, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2501007
Info:   67nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.R2460Q, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2501262
Info:   67nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.R2460Q, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2501263
Info:   67nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.V10514A, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2501802
Info:   69nt amplicon; crosses exon-intron junction; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.V10514A, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2501803
Info:   69nt amplicon; crosses exon-intron junction; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.R11667G, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2502042
Info:   78nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.R11667G, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2502043
Info:   78nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.G15665G, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2502448
Info:   70nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.G15665G, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2502449
Info:   70nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.L11636P, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2502554
Info:   63nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.L11636P, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2502555
Info:   63nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.K26228K, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2502690
Info:   120nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.K26228K, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2502691
Info:   120nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.D10326N, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2502716
Info:   68nt amplicon; crosses exon-intron junction; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.D10326N, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2502717
Info:   68nt amplicon; crosses exon-intron junction; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.R23644R, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2503156
Info:   91nt amplicon; crosses exon-intron junction; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.R23644R, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2503157
Info:   91nt amplicon; crosses exon-intron junction; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.T21494A, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2504180
Info:   65nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.T21494A, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2504181
Info:   65nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.L15222P, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2505006
Info:   100nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.L15222P, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2505007
Info:   100nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.R6043Q, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2505082
Info:   67nt amplicon; crosses exon-intron junction; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.R6043Q, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2505083
Info:   67nt amplicon; crosses exon-intron junction; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.R8771H, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2505180
Info:   68nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.R8771H, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2505181
Info:   68nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:TTN p.T1861A, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2505802
Info:   61nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:TTN WT for p.T1861A, Human
titin

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2505803
Info:   61nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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