Gene:  TAB1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1 which is known to mediate various intracellular signaling pathways such as those induced by TGF beta interleukin 1 and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1 while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha) and thus represents an alternative activation pathway in addition to the MAPKK pathways which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: TAB1, Chicken
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qGgaCED0027015
List Price:    $102.00
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PrimePCR™ Probe Assay: TAB1, Chicken
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Assay Type: Probe
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qGgaCEP0011481
List Price:    $196.00
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