Gene:  SLC6A6, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Taurine (2-aminoethanesulfonic acid) is a major intracellular amino acid in mammals. It is involved in a number of important physiologic processes including bile acid conjugation in hepatocytes modulation of calcium flux and neural excitability osmoregulation detoxification and membrane stabilization. The cells of most organisms respond to hypertonicity by the intracellular accumulation of high concentrations of small organic solutes (osmolytes) that in contrast to high concentrations of electrolytes do not perturb the function of macromolecules. The renal medulla is normally the only tissue in mammals that undergoes wide shifts in tonicity. Its hypertonicity when the kidney is excreting a concentrated urine is fundamental to water conservation. The taurine content of the renal medulla of rats infused with 5% NaCl is higher than that in controls suggesting that taurine behaves as an osmolyte in the renal medulla. Indeed taurine functions as an osmolyte in Madin-Darby canine kidney (MDCK) cells. When MDCK cells cultured in isotonic medium are switched to hypertonic medium their content of taurine doubles through the taking up of taurine from the medium. Taurine transport in these cells is dependent on sodium and chloride ions and is localized primarily in the basolateral plasma membrane (summary by Uchida et al. 1992 [PubMed 1518851]).[supplied by OMIM Jan 2011]

PrimePCR™ SYBR® Green Assay: SLC6A6, Human
solute carrier family 6 (neurotransmitter transporter, taurine), member 6

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0044381
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0051643
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PrimePCR™ SYBR® Green Assay: SLC6A6, Human
solute carrier family 6 (neurotransmitter transporter, taurine), member 6

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0022308
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PrimePCR™ Probe Assay: SLC6A6, Human
solute carrier family 6 (neurotransmitter transporter, taurine), member 6

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0051643
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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