Gene:  SLC4A1, Human

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The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens which form the Diego blood group system. Southeast Asian ovalocytosis (SAO Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq Jul 2008]

Select a product type :   All   qPCR   ddPCR
PrimePCR™ SYBR® Green Assay: SLC4A1, Human
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0003797
Info:   Same primer pair as used in probe assay qHsaCEP0024831
List Price:    $130.00
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PrimePCR™ Probe Assay: SLC4A1, Human
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)

Assay Type: Probe
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0024831
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: SLC4A1, Human
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5002172
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0003797; Exonic
List Price:    $130.00
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PrimePCR™ ddPCR™ Expression Probe Assay: SLC4A1, Human
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5026688
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0024831; Exonic
 
Fluorophore:   FAM
List Price:    $195.00
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PrimePCR™ ddPCR™ Expression Probe Assay: SLC4A1, Human
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5026689
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0024831; Exonic
 
Fluorophore:   HEX
List Price:    $195.00
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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