Gene:  SENP6, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Ubiquitin-like molecules (UBLs) such as SUMO1 (UBL1; MIM 601912) are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin UBLs are synthesized as precursor proteins with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus the tail sequences of the UBL precursors need to be removed by UBL-specific proteases such as SENP6 prior to their conjugation to target proteins (Kim et al. 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter 2008 [PubMed 18799455]).[supplied by OMIM Jun 2009]

PrimePCR™ SYBR® Green Assay: SENP6, Human
SUMO1/sentrin specific peptidase 6

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0043453
Info:   Recommended - best efficiency; Same primer pair as used in probe assay qHsaCEP0050715
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PrimePCR™ SYBR® Green Assay: SENP6, Human
SUMO1/sentrin specific peptidase 6

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0007054
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PrimePCR™ Probe Assay: SENP6, Human
SUMO1/sentrin specific peptidase 6

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0050715
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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