Gene:  SACS, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes the sacsin protein which includes a UbL domain at the N-terminus a DnaJ domain and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system also found in skin skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that "the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins" (Parfitt et al. PubMed: 19208651). [provided by RefSeq Apr 2012]

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PrimePCR™ SYBR® Green Assay: SACS, Human
spastic ataxia of Charlevoix-Saguenay (sacsin)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0045543
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0052804
List Price:    $125.00
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PrimePCR™ SYBR® Green Assay: SACS, Human
spastic ataxia of Charlevoix-Saguenay (sacsin)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0007126
List Price:    $125.00
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PrimePCR™ Probe Assay: SACS, Human
spastic ataxia of Charlevoix-Saguenay (sacsin)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0052804
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: SACS, Human
spastic ataxia of Charlevoix-Saguenay (sacsin)

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5010065
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0045543; exonic
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: SACS, Human
spastic ataxia of Charlevoix-Saguenay (sacsin)

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5014845
Info:   EG; Same primer pair as used in qPCR assay qHsaCID0007126; Intron-spanning
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression Probe Assay: SACS, Human
spastic ataxia of Charlevoix-Saguenay (sacsin)

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5038440
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0052804; exonic
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: SACS, Human
spastic ataxia of Charlevoix-Saguenay (sacsin)

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5038441
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0052804; exonic
 
Fluorophore:   HEX
List Price:    $190.00
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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