Gene:  RUNX1T1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq Nov 2010]

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PrimePCR™ SYBR® Green Assay: RUNX1T1, Human
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

Assay Type: SYBR® Green
Assay Design: intron_spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0038554
Info:   Same primer pair as used in probe assay qHsaCIP0041276
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PrimePCR™ Probe Assay: RUNX1T1, Human
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

Assay Type: Probe
Assay Design: intron_spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0041276
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PrimePCR™ ddPCR™ Copy Number Assay: RUNX1T1, Human
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000393
 
Fluorophore:   FAM
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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