Gene:  RPL7A, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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PrimePCR
Lookup Tool
Design and Validation of Real-Time PCR Primers
Pathway Curation
and Array Design Strategy
Control and Reference Assays for Real-Time PCR

Cytoplasmic ribosomes organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors including thyroid hormone receptor and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24 U36a U36b and U36c small nucleolar RNA genes which are located in its second fifth fourth and sixth introns respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq Jul 2008]

Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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