Gene:  PDHX, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits E1 E2 and E3 two regulatory subunits E1 kinase and E1 phosphatase and a non-catalytic subunit E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq Oct 2009]

Select a product type :   All   qPCR   ddPCR
PrimePCR™ SYBR® Green Assay: PDHX, Human
pyruvate dehydrogenase complex, component X

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0037881
Info:   Same primer pair as used in probe assay qHsaCIP0040604
List Price:    $130.00
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PrimePCR™ Probe Assay: PDHX, Human
pyruvate dehydrogenase complex, component X

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0040604
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: PDHX, Human
pyruvate dehydrogenase complex, component X

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5025148
Info:   EG; Same primer pair as used in qPCR assay qHsaCID0037881; Intron-spanning
List Price:    $130.00
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PrimePCR™ ddPCR™ Expression Probe Assay: PDHX, Human
pyruvate dehydrogenase complex, component X

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5058982
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0040604; Intron-spanning
 
Fluorophore:   FAM
List Price:    $195.00
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PrimePCR™ ddPCR™ Expression Probe Assay: PDHX, Human
pyruvate dehydrogenase complex, component X

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5058983
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0040604; Intron-spanning
 
Fluorophore:   HEX
List Price:    $195.00
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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