Gene:  MKNK2, Human

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This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E) thus playing important roles in the initiation of mRNA translation oncogenic transformation and malignant cell proliferation. In addition to eIF4E this protein also interacts with von Hippel-Lindau tumor suppressor (VHL) ring-box 1 (Rbx1) and Cullin2 (Cul2) which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation and in subcellular localization. [provided by RefSeq Aug 2011]

PrimePCR™ SYBR® Green Assay: MKNK2, Human
MAP kinase interacting serine/threonine kinase 2

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0014291
Info:   Same primer pair as used in probe assay qHsaCIP0029303
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PrimePCR™ Probe Assay: MKNK2, Human
MAP kinase interacting serine/threonine kinase 2

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0029303
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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