Gene:  MDM4, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity and have been shown to be overexpressed in a variety of human cancers. However unlike MDM2 which degrades p53 this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq Feb 2011]

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PrimePCR™ SYBR® Green Assay: MDM4, Human
Mdm4 p53 binding protein homolog (mouse)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0038792
Info:   Same primer pair as used in probe assay qHsaCEP0041514
List Price:    $138.00
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PrimePCR™ Probe Assay: MDM4, Human
Mdm4 p53 binding protein homolog (mouse)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0041514
List Price:    $202.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: MDM4, Human
Mdm4 p53 binding protein homolog (mouse)

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5006687
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0038792; exonic
List Price:    $138.00
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PrimePCR™ ddPCR™ Copy Number Assay: MDM4, Human
Mdm4 p53 binding protein homolog (mouse)

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000592
Info:   FAM; 70nt amplicon; exonic; FAM version of MDM4 (dHsaCP2506520)
 
Fluorophore:   FAM
List Price:    $254.00
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PrimePCR™ ddPCR™ Copy Number Assay: MDM4, Human
Mdm4 p53 binding protein homolog (mouse)

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP2506520
Info:   HEX; 70nt amplicon; exonic; HEX version of MDM4 (dHsaCP1000592)
 
Fluorophore:   HEX
List Price:    $254.00
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PrimePCR™ ddPCR™ Expression Probe Assay: MDM4, Human
Mdm4 p53 binding protein homolog (mouse)

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5031686
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0041514; exonic
 
Fluorophore:   FAM
List Price:    $207.00
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PrimePCR™ ddPCR™ Expression Probe Assay: MDM4, Human
Mdm4 p53 binding protein homolog (mouse)

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5031687
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0041514; exonic
 
Fluorophore:   HEX
List Price:    $207.00
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