Gene:  LIMK2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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There are approximately 40 known eukaryotic LIM proteins so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK a downstream effector of Rho and the encoded protein in turn phosphorylates cofilin inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: LIMK2, Human
LIM domain kinase 2

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0022037
Info:   Same primer pair as used in probe assay qHsaCIP0033265
List Price:    $174.00
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PrimePCR™ Probe Assay: LIMK2, Human
LIM domain kinase 2

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0033265
List Price:    $255.00
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