Gene:  LAMC3, Human

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Laminins a family of extracellular matrix glycoproteins are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion differentiation migration signaling neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha beta and gamma (formerly A B1 and B2 respectively) and they form a cruciform structure consisting of 3 short arms each formed by a different chain and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown but some of the chains have been shown to differ with respect to their tissue distribution presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin gamma 3. The gamma 3 chain is most similar to the gamma 1 chain and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin heart lung and the reproductive tracts. In skin it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung oviduct epididymis ductus deferens and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq Aug 2011]

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PrimePCR™ SYBR® Green Assay: LAMC3, Human
laminin, gamma 3

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0042129
Info:   Same primer pair as used in probe assay qHsaCEP0049392
List Price:    $125.00
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PrimePCR™ SYBR® Green Assay: LAMC3, Human
laminin, gamma 3

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0018418
Info:   Recommended - best coverage
List Price:    $125.00
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PrimePCR™ Probe Assay: LAMC3, Human
laminin, gamma 3

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0049392
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: LAMC3, Human
laminin, gamma 3

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5007089
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0042129; exonic
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: LAMC3, Human
laminin, gamma 3

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5023239
Info:   EG; Same primer pair as used in qPCR assay qHsaCID0018418; Intron-spanning
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression Probe Assay: LAMC3, Human
laminin, gamma 3

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5032490
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0049392; exonic
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: LAMC3, Human
laminin, gamma 3

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5032491
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0049392; exonic
 
Fluorophore:   HEX
List Price:    $190.00
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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