Gene:  KLKB1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation fibrinolysis kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: KLKB1, Human
kallikrein B, plasma (Fletcher factor) 1

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0046213
Info:   Same primer pair as used in probe assay qHsaCEP0053474
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PrimePCR™ SYBR® Green Assay: KLKB1, Human
kallikrein B, plasma (Fletcher factor) 1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0006807
Info:   Recommended - best coverage
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PrimePCR™ Probe Assay: KLKB1, Human
kallikrein B, plasma (Fletcher factor) 1

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0053474
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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