Gene:  INPP5D, Human

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This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain an inositol phosphatase domain and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane the protein hydrolyzes the 5' phosphate from phosphatidylinositol (345)-trisphosphate and inositol-1345-tetrakisphosphate thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: INPP5D, Human
inositol polyphosphate-5-phosphatase, 145kDa

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0014830
Info:   Same primer pair as used in probe assay qHsaCIP0029573
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PrimePCR™ Probe Assay: INPP5D, Human
inositol polyphosphate-5-phosphatase, 145kDa

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0029573
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Number Description Download
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LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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