Gene:  HMGCR, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Aug 2008]

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PrimePCR™ SYBR® Green Assay: HMGCR, Human
3-hydroxy-3-methylglutaryl-CoA reductase

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0043471
Info:   Same primer pair as used in probe assay qHsaCEP0050733
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PrimePCR™ SYBR® Green Assay: HMGCR, Human
3-hydroxy-3-methylglutaryl-CoA reductase

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0008700
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PrimePCR™ Probe Assay: HMGCR, Human
3-hydroxy-3-methylglutaryl-CoA reductase

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0050733
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PrimePCR™ ddPCR™ Copy Number Assay: HMGCR, Human
3-hydroxy-3-methylglutaryl-CoA reductase

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000430
Info:   65nt amplicon; intronic
 
Fluorophore:   FAM
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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