Gene:  HEXB, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that together with the cofactor GM2 activator protein catalyzes the degradation of the ganglioside GM2 and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits alpha and beta which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: HEXB, Human
hexosaminidase B (beta polypeptide)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0042124
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0049387
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PrimePCR™ SYBR® Green Assay: HEXB, Human
hexosaminidase B (beta polypeptide)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0013279
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PrimePCR™ Probe Assay: HEXB, Human
hexosaminidase B (beta polypeptide)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0049387
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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