Gene:  HAS2, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions including space filling lubrication of joints and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis and human and murine hyaluronan synthase 1. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: HAS2, Human
hyaluronan synthase 2

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0046759
Info:   Same primer pair as used in probe assay qHsaCEP0054020
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PrimePCR™ SYBR® Green Assay: HAS2, Human
hyaluronan synthase 2

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0015405
Info:   Recommended - best coverage
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PrimePCR™ Probe Assay: HAS2, Human
hyaluronan synthase 2

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0054020
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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