Gene:  GRM1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology putative signal transduction mechanisms and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4 GRM6 GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq Jul 2008]

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PrimePCR™ SYBR® Green Assay: GRM1, Human
glutamate receptor, metabotropic 1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0009885
Info:   Same primer pair as used in probe assay qHsaCIP0027369
List Price:    $125.00
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PrimePCR™ Probe Assay: GRM1, Human
glutamate receptor, metabotropic 1

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0027369
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: GRM1, Human
glutamate receptor, metabotropic 1

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5016693
Info:   EG; Same primer pair as used in qPCR assay qHsaCID0009885; Intron-spanning
List Price:    $125.00
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PrimePCR™ ddPCR™ Copy Number Assay: GRM1, Human
glutamate receptor, metabotropic 1

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000125
Info:   FAM: 61nt amplicon; exonic
 
Fluorophore:   FAM
List Price:    $230.00
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PrimePCR™ ddPCR™ Copy Number Assay: GRM1, Human
glutamate receptor, metabotropic 1

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP2507054
Info:   HEX; 61nt amplicon; exonic; HEX version of GRM1 (dHsaCP1000125)
 
Fluorophore:   HEX
List Price:    $230.00
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PrimePCR™ ddPCR™ Expression Probe Assay: GRM1, Human
glutamate receptor, metabotropic 1

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5048858
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0027369; Intron-spanning
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: GRM1, Human
glutamate receptor, metabotropic 1

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5048859
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0027369; Intron-spanning
 
Fluorophore:   HEX
List Price:    $190.00
Your Price:   Log In
Quantity:  
 
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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