Gene:  FGFR4, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The protein encoded by this gene is a member of the fibroblast growth factor receptor family where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region composed of three immunoglobulin-like domains a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors setting in motion a cascade of downstream signals ultimately influencing mitogenesis and differentiation. The genomic organization of this gene compared to members 1-3 encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and although its specific function is unknown it is overexpressed in gynecological tumor samples suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: FGFR4, Human
fibroblast growth factor receptor 4

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0001143
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PrimePCR™ SYBR® Green Assay: FGFR4, Human
fibroblast growth factor receptor 4

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0045915
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0053176
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PrimePCR™ Probe Assay: FGFR4, Human
fibroblast growth factor receptor 4

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0053176
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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