Gene:  FBXW4, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene is a member of the F-box/WD-40 gene family which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq Jul 2008]

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PrimePCR™ SYBR® Green Assay: FBXW4, Human
F-box and WD repeat domain containing 4

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0006739
Info:   Same primer pair as used in probe assay qHsaCIP0026275
List Price:    $130.00
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PrimePCR™ Probe Assay: FBXW4, Human
F-box and WD repeat domain containing 4

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0026275
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: FBXW4, Human
F-box and WD repeat domain containing 4

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5014682
Info:   EG; Same primer pair as used in qPCR assay qHsaCID0006739; Intron-spanning
List Price:    $130.00
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PrimePCR™ ddPCR™ Expression Probe Assay: FBXW4, Human
F-box and WD repeat domain containing 4

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5046970
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0026275; Intron-spanning
 
Fluorophore:   FAM
List Price:    $195.00
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PrimePCR™ ddPCR™ Expression Probe Assay: FBXW4, Human
F-box and WD repeat domain containing 4

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5046971
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0026275; Intron-spanning
 
Fluorophore:   HEX
List Price:    $195.00
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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