This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions membrane phospholipids and factor VIII. Alterations of this gene including point mutations insertions and deletions cause factor IX deficiency which is a recessive X-linked disorder also called hemophilia B or Christmas disease. [provided by RefSeq Jul 2008]
PrimePCR™ PreAmp for SYBR® Green Assay: F9, Human
PrimePCR™ Template for SYBR® Green Assay: F9, Human
PrimePCR™ PreAmp for Probe Assay: F9, Human
PrimePCR™ Template for Probe Assay: F9, Human
