Gene:  F13A1, Human

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This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion the plasma factor XIII dissociates its B subunits and yields the same active enzyme factor XIIIa as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency characterized by the lack of both the A and B subunits; and type II deficiency characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency defective wound healing and habitual abortion. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: F13A1, Human
coagulation factor XIII, A1 polypeptide

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0044045
Info:   Same primer pair as used in probe assay qHsaCEP0051307
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PrimePCR™ SYBR® Green Assay: F13A1, Human
coagulation factor XIII, A1 polypeptide

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0011749
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PrimePCR™ Probe Assay: F13A1, Human
coagulation factor XIII, A1 polypeptide

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0051307
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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