Gene:  ESRRG, Human

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This gene encodes a member of the estrogen receptor-related receptor (ESRR) family which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes co-regulators and promoters and by targeting the same set of genes the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters modulates cell proliferation and estrogen signaling in breast cancer and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq Aug 2011]

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PrimePCR™ SYBR® Green Assay: ESRRG, Human
estrogen-related receptor gamma

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0037761
Info:   Same primer pair as used in probe assay qHsaCIP0040484
List Price:    $125.00
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PrimePCR™ Probe Assay: ESRRG, Human
estrogen-related receptor gamma

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0040484
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: ESRRG, Human
estrogen-related receptor gamma

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5025114
Info:   EG; Same primer pair as used in qPCR assay qHsaCID0037761; Intron-spanning
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression Probe Assay: ESRRG, Human
estrogen-related receptor gamma

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5058914
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0040484; Intron-spanning
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: ESRRG, Human
estrogen-related receptor gamma

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5058915
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0040484; Intron-spanning
 
Fluorophore:   HEX
List Price:    $190.00
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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