Gene:  COX10, Human

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Cytochrome c oxidase (COX) the terminal component of the mitochondrial respiratory chain catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation which results in the substitution of a lysine for an asparagine (N204K) is identified to be responsible for cytochrome c oxidase deficiency. In addition this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq Jul 2008]

Select a product type :   All   qPCR   ddPCR
PrimePCR™ SYBR® Green Assay: COX10, Human
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0041926
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0049189
List Price:    $130.00
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PrimePCR™ SYBR® Green Assay: COX10, Human
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0020867
List Price:    $130.00
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Add to Custom Plate
PrimePCR™ Probe Assay: COX10, Human
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0049189
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: COX10, Human
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5006907
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0041926; exonic
List Price:    $130.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: COX10, Human
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5189727
Info:   EG; Same primer pair as used in qPCR assay qHsaCID0020867; Intron-spanning
List Price:    $130.00
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PrimePCR™ ddPCR™ Expression Probe Assay: COX10, Human
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5032126
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0049189; exonic
 
Fluorophore:   FAM
List Price:    $195.00
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PrimePCR™ ddPCR™ Expression Probe Assay: COX10, Human
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5032127
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0049189; exonic
 
Fluorophore:   HEX
List Price:    $195.00
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Quantity:  
 
    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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