Gene:  CLEC4M, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq Feb 2009]

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PrimePCR™ SYBR® Green Assay: CLEC4M, Human
C-type lectin domain family 4, member M

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0003485
Info:   Same primer pair as used in probe assay qHsaCEP0024725
List Price:    $130.00
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PrimePCR™ Probe Assay: CLEC4M, Human
C-type lectin domain family 4, member M

Assay Type: Probe
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0024725
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: CLEC4M, Human
C-type lectin domain family 4, member M

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5001932
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0003485; Exonic
List Price:    $130.00
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PrimePCR™ ddPCR™ Expression Probe Assay: CLEC4M, Human
C-type lectin domain family 4, member M

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5026532
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0024725; Exonic
 
Fluorophore:   FAM
List Price:    $195.00
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PrimePCR™ ddPCR™ Expression Probe Assay: CLEC4M, Human
C-type lectin domain family 4, member M

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5026533
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0024725; Exonic
 
Fluorophore:   HEX
List Price:    $195.00
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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