Gene:  CACNA1A, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes including muscle contraction hormone or neurotransmitter release and gene expression. Calcium channels are multisubunit complexes composed of alpha-1 beta alpha-2/delta and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms alpha-1A B C D E and S. This gene encodes the alpha-1A subunit which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants the (CAG)n-repeats occur in the 3' UTR and are not associated with any disease. But in another set of variants an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq Mar 2010]

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PrimePCR™ SYBR® Green Assay: CACNA1A, Human
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0016923
Info:   Same primer pair as used in probe assay qHsaCIP0030898
List Price:    $125.00
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PrimePCR™ Probe Assay: CACNA1A, Human
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0030898
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: CACNA1A, Human
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5022084
Info:   EG; Same primer pair as used in qPCR assay qHsaCID0016923; Intron-spanning
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression Probe Assay: CACNA1A, Human
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5055040
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0030898; Intron-spanning
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: CACNA1A, Human
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5055041
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0030898; Intron-spanning
 
Fluorophore:   HEX
List Price:    $190.00
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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