Gene:  BCL2L11, Human

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The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family including BCL2 BCL2L1/BCL-X(L) and MCL1 and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF) as well as by the forkhead transcription factor FKHR-L1 which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: BCL2L11, Human
BCL2-like 11 (apoptosis facilitator)

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0005030
Info:   Same primer pair as used in probe assay qHsaCEP0025251
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PrimePCR™ Probe Assay: BCL2L11, Human
BCL2-like 11 (apoptosis facilitator)

Assay Type: Probe
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0025251
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
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LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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