Gene:  AXIN2, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The Axin-related protein Axin2 presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway like its rodent homologs mouse conductin/rat axil. In mouse conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon) beta-catenin glycogen synthase kinase 3-beta and conductin which leads to the degradation of beta-catenin. Apparently the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24 a region that shows frequent loss of heterozygosity in breast cancer neuroblastoma and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: AXIN2, Human
axin 2

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0017930
Info:   Same primer pair as used in probe assay qHsaCIP0031547
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PrimePCR™ Probe Assay: AXIN2, Human
axin 2

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0031547
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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