Gene:  ATXN7, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum brain stem and spinal cord. Clinically ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous with five genetic loci designated spinocerebellar ataxia (SCA) 1 2 3 4 and 6 being assigned to five different chromosomes. ADCAII which always presents with retinal degeneration (SCA7) and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5) are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3 and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus) compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq Apr 2010]

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PrimePCR™ SYBR® Green Assay: ATXN7, Human
ataxin 7

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0004087
Info:   Same primer pair as used in probe assay qHsaCEP0024914
List Price:    $125.00
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PrimePCR™ Probe Assay: ATXN7, Human
ataxin 7

Assay Type: Probe
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0024914
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: ATXN7, Human
ataxin 7

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5002402
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0004087; Exonic
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression Probe Assay: ATXN7, Human
ataxin 7

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5026814
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0024914; Exonic
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: ATXN7, Human
ataxin 7

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5026815
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0024914; Exonic
 
Fluorophore:   HEX
List Price:    $190.00
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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