Gene:  APPL2, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5 which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain a central pleckstrin homology (PH) domain and a C-terminal phosphotyrosine binding (PTB) domain and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome also known as Phelan-McDermid syndrome. [provided by RefSeq Oct 2011]

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PrimePCR™ SYBR® Green Assay: APPL2, Human
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0002838
List Price:    $130.00
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PrimePCR™ SYBR® Green Assay: APPL2, Human
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0044660
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0051922
List Price:    $130.00
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Add to Custom Plate
PrimePCR™ Probe Assay: APPL2, Human
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0051922
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: APPL2, Human
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5001464
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0002838; Exonic
List Price:    $130.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: APPL2, Human
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5009286
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0044660; exonic
List Price:    $130.00
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PrimePCR™ ddPCR™ Expression Probe Assay: APPL2, Human
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5036884
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0051922; exonic
 
Fluorophore:   FAM
List Price:    $195.00
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PrimePCR™ ddPCR™ Expression Probe Assay: APPL2, Human
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5036885
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0051922; exonic
 
Fluorophore:   HEX
List Price:    $195.00
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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