Gene:  APH1A, Human

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This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product or the paralogous anterior pharynx defective 1 homolog B (APH1B) along with the presenilin nicastrin and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq Aug 2011]

PrimePCR™ SYBR® Green Assay: APH1A, Human
anterior pharynx defective 1 homolog A (C. elegans)

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0007820
Info:   Same primer pair as used in probe assay qHsaCEP0025677
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PrimePCR™ Probe Assay: APH1A, Human
anterior pharynx defective 1 homolog A (C. elegans)

Assay Type: Probe
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0025677
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Number Description Download
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LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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