Gene:  ADD3, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin originally purified from human erythrocytes was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C the binding site for calmodulin and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq Jul 2008]

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PrimePCR™ SYBR® Green Assay: ADD3, Human
adducin 3 (gamma)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0007060
Info:   Same primer pair as used in probe assay qHsaCIP0026334
List Price:    $125.00
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PrimePCR™ Probe Assay: ADD3, Human
adducin 3 (gamma)

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0026334
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: ADD3, Human
adducin 3 (gamma)

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5014792
Info:   EG; Same primer pair as used in qPCR assay qHsaCID0007060; Intron-spanning
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression Probe Assay: ADD3, Human
adducin 3 (gamma)

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5047060
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0026334; Intron-spanning
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: ADD3, Human
adducin 3 (gamma)

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5047061
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0026334; Intron-spanning
 
Fluorophore:   HEX
List Price:    $190.00
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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