Gene:  ACO1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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PrimePCR
Lookup Tool
Design and Validation of Real-Time PCR Primers
Pathway Curation
and Array Design Strategy
Control and Reference Assays for Real-Time PCR

Aconitase 1 also known as iron regulatory element binding protein 1 (IREB1) is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity and hence grouped with the aconitase family of enzymes. [provided by RefSeq Jul 2008]

    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download