PrimePCR™ lncRNA® Probe Assay:PABPN1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression.

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   Same primer pair as used in SYBR assay qhsaLED0134385

List Price:    $247.00
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PrimePCR™ IncRNA PreAmp for Probe Assay: PABPN1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ IncRNA Template for Probe Assay: PABPN1, Human
Reaction:     4 billion copies/200 µl
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   lncRNA Expression
Unique Assay ID:   qhsaLEP0211625
Assay Design:   exonic
Chromosome Location:   chr14:23325998-23326150question
Amplicon Length:   123
Splice Variants Targeted:   ENST00000397276 ENST00000216727
LNCipedia Splice Variants Targeted:   lnc-BCL2L2-PABPN1-1:3 lnc-BCL2L2-PABPN1-1:2

Gene Information

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq Dec 2010]

Gene Symbol:   PABPN1
Gene Name:   poly(A) binding protein, nuclear 1
Aliases:   OPMD, PAB2, PABII, PABP-2, PABP2
RefSeq:   NC_000014.8 NG_008239.1 NT_026437.12
Ensembl:   ENSG00000100836
LNCipedia:   lnc-BCL2L2-PABPN1-1
Entrez:   8106
Chromosome Mapping:   14q11.2-q13
Gene Strand:   Not Available

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