PrimePCR™ lncRNA® Probe Assay:ATF6, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression.

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   Same primer pair as used in SYBR assay qhsaLED0103279

List Price:    $247.00
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PrimePCR™ IncRNA PreAmp for Probe Assay: ATF6, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ IncRNA Template for Probe Assay: ATF6, Human
Reaction:     4 billion copies/200 µl
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   lncRNA Expression
Unique Assay ID:   qhsaLEP0180519
Assay Design:   exonic
Chromosome Location:   chr1:161959865-161960014question
Amplicon Length:   120
Splice Variants Targeted:   ENST00000367942
LNCipedia Splice Variants Targeted:   lnc-NOS1AP-2:1

Gene Information

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer and following ER stress-induced proteolysis it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq Aug 2011]

Gene Symbol:   ATF6
Gene Name:   activating transcription factor 6
Aliases:   ATF6A
RefSeq:   NC_000001.10 NT_004487.19
Ensembl:   ENSG00000118217
LNCipedia:   lnc-NOS1AP-2
Entrez:   22926
Chromosome Mapping:   1q22-q23
Gene Strand:   Not Available

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