PrimePCR™ Probe Assay: AZIN1, Chicken


Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $202.00
Your Price:   Log In

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qGgaCIP0004325
Assay Design:   Intron-spanning
Chromosome Location:   2:129019559-129022301question
Amplicon Length:   114
Splice Variants Targeted:   ENSGALT00000036606

Gene Information

The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. [provided by RefSeq, Sep 2014]

Gene Symbol:   AZIN1
Gene Name:   Ornithine decarboxylase antizyme inhibitor
Aliases:   Not Available
RefSeq:   NM_001008729
Ensembl:   ENSGALG00000016056
Entrez:   420254
UniGene:   Gga.8926
Chromosome Mapping:   2

Number Description Download