PrimePCR™ Probe Assay: OAZ2, Dog

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $196.00
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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qCfaCIP0015516
Assay Design:   Intron-spanning
Chromosome Location:   30:29125032-29126389question
Amplicon Length:   114
Splice Variants Targeted:   ENSCAFT00000027077

Gene Information

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014]

Gene Symbol:   OAZ2
Gene Name:   Ornithine decarboxylase antizyme 2
Aliases:   Not Available
RefSeq:   XM_005638698
Ensembl:   ENSCAFG00000017097
Entrez:   478343
UniGene:   Cfa.12080
Chromosome Mapping:   30

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