PrimePCR™ SYBR® Green Assay: AZIN1, Dog

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qCfaCID0024315
Assay Design:   Intron-spanning
Chromosome Location:   13:4373254-4375103question
Amplicon Length:   111
Splice Variants Targeted:   ENSCAFT00000000990

Gene Information

The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. [provided by RefSeq, Sep 2014]

Gene Symbol:   AZIN1
Gene Name:   Antizyme inhibitor 1
Aliases:   Not Available
RefSeq:   XM_005627842 XM_844213
Ensembl:   ENSCAFG00000000643
Entrez:   475058
UniGene:   Cfa.20071,Cfa.47779
Chromosome Mapping:   13

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