PrimePCR™ Probe Assay: OAZ3, Cow

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qBtaCEP0027730
Assay Design:   Exonic
Chromosome Location:   3:19054073-19054199question
Amplicon Length:   97
Splice Variants Targeted:   ENSBTAT00000046490

Gene Information

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. This transcript initiates translation from a non-AUG (CUG) start codon that is highly conserved amongst the antizyme 3 orthologs. [provided by RefSeq, Aug 2014]

Gene Symbol:   OAZ3
Gene Name:   Bos taurus ornithine decarboxylase antizyme 3 (OAZ3), mRNA.
Aliases:   Not Available
RefSeq:   NM_001172708
Ensembl:   ENSBTAG00000021591
Entrez:   531865
UniGene:   Bt.54155
Chromosome Mapping:   3

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