PrimePCR™ ddPCR™ Expression EvaGreen® Assay: Eif4g2, Mouse

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qMmuCID0016742; Intron-spanning

List Price:    $130.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dMmuEG5080240
Chromosome Location:   7:111078489-111080226question
Amplicon Length:   80

Gene Information

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F) which is a cap binding protein complex that consists of three subunits: eIF4A eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G in addition contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   Eif4g2
Gene Name:   Eukaryotic translation initiation factor 4, gamma 2
Aliases:   AA589388, DAP-5, E130105L11Rik, Nat1, Natm1, p97
RefSeq:   NC_000073.6 NT_039433.8
Ensembl:   ENSMUSG00000005610
Entrez:   13690
UniGene:   Mm.185453
Chromosome Mapping:   7 F1|7 51.52 cM

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