PrimePCR™ ddPCR™ Expression Probe Assay: Trp53, Mouse

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qMmuCIP0032520; Intron-spanning

 
Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dMmuCPE5116669
Chromosome Location:   11:69580402-69587378question
Amplicon Length:   195

Gene Information

This gene encodes tumor protein p53 which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest apoptosis senescence DNA repair or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation DNA-binding and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter in contrast to alternative promoters of the human gene and transcribes a few of splice variants which encode different isoforms although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq Jul 2008]

Gene Symbol:   Trp53
Gene Name:   Transformation related protein 53
Aliases:   Tp53, bbl, bfy, bhy, p44, p53
RefSeq:   NC_000077.6 NT_096135.6
Ensembl:   ENSMUSG00000059552
Entrez:   22059
UniGene:   Mm.222
Chromosome Mapping:   11 B2-C|11 39.0 cM

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