PrimePCR™ ddPCR™ Expression Probe Assay: Ctnnb1, Mouse


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qMmuCIP0032159; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dMmuCPE5115990
Chromosome Location:   9:120957622-120958633question
Amplicon Length:   180

Gene Information

This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile it also binds alpha-catenin which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin adenomatous polyposis coli (APC) casein kinase I and GSK3B then ubiquitylated by beta-TrCP and degraded by the proteasome. However in the presence of Wnt signal the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus where it binds various transcription factors and together with these factors regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq Sep 2009]

Gene Symbol:   Ctnnb1
Gene Name:   Catenin (cadherin associated protein), beta 1
Aliases:   Bfc, Catnb, Mesc
RefSeq:   NC_000075.6 NT_039482.8
Ensembl:   ENSMUSG00000006932
Entrez:   12387
UniGene:   Mm.291928
Chromosome Mapping:   9 F4|9 72.0 cM

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